PowerMAG series

PowerMAG series

POWERMAG RESERCH series general functions

Stable pulse amplitude and width with full power output (100% intensity) up to 30 Hz for all stimulators.
There is no reduction in pulse output during stimulation.
Full external control is possible with analog, digital and trigger interfaces.
All single pulses can be set freely (shape, direction, intensity).
Continuous EEG recorded online with no power supply noise or recharging artifacts (not for PowerMAG LAB series)
A high speed synchronous output interface is available for phase synchronization with EEG amplifiers.

PowerMAG QPS

PoweMAG ppTMS

PoweMAG EEG

PoweMAG LAB

POWERMAG RESERCH series general functions

Stable pulse amplitude and width with full power output (100% intensity) up to 30 Hz for all stimulators.
There is no reduction in pulse output during stimulation.
Full external control is possible with analog, digital and trigger interfaces.
All single pulses can be set freely (shape, direction, intensity).
Continuous EEG recorded online with no power supply noise or recharging artifacts (not for PowerMAG LAB series)
A high speed synchronous output interface is available for phase synchronization with EEG amplifiers.

POWERMAG RESERCH series general functions

Stable pulse amplitude and width with full power output (100% intensity) up to 30 Hz for all stimulators.
There is no reduction in pulse output during stimulation.
Full external control is possible with analog, digital and trigger interfaces.
All single pulses can be set freely (shape, direction, intensity).
Continuous EEG recorded online with no power supply noise or recharging artifacts (not for PowerMAG LAB series)
A high speed synchronous output interface is available for phase synchronization with EEG amplifiers.

POWERMAG RESERCH series general functions

Stable pulse amplitude and width with full power output (100% intensity) up to 30 Hz for all stimulators.
There is no reduction in pulse output during stimulation.
Full external control is possible with analog, digital and trigger interfaces.
All single pulses can be set freely (shape, direction, intensity).
Continuous EEG recorded online with no power supply noise or recharging artifacts (not for PowerMAG LAB series)
A high speed synchronous output interface is available for phase synchronization with EEG amplifiers.

POWERMAG RESERCH series general functions

Stable pulse amplitude and width with full power output (100% intensity) up to 30 Hz for all stimulators.
There is no reduction in pulse output during stimulation.
Full external control is possible with analog, digital and trigger interfaces.
All single pulses can be set freely (shape, direction, intensity).
Continuous EEG recorded online with no power supply noise or recharging artifacts (not for PowerMAG LAB series)
A high speed synchronous output interface is available for phase synchronization with EEG amplifiers.

POWERMAG RESERCH series general functions

Stable pulse amplitude and width with full power output (100% intensity) up to 30 Hz for all stimulators.
There is no reduction in pulse output during stimulation.
Full external control is possible with analog, digital and trigger interfaces.
All single pulses can be set freely (shape, direction, intensity).
Continuous EEG recorded online with no power supply noise or recharging artifacts (not for PowerMAG LAB series)
A high speed synchronous output interface is available for phase synchronization with EEG amplifiers.

POWERMAG RESERCH series general functions

Stable pulse amplitude and width with full power output (100% intensity) up to 30 Hz for all stimulators.
There is no reduction in pulse output during stimulation.
Full external control is possible with analog, digital and trigger interfaces.
All single pulses can be set freely (shape, direction, intensity).
Continuous EEG recorded online with no power supply noise or recharging artifacts (not for PowerMAG LAB series)
A high speed synchronous output interface is available for phase synchronization with EEG amplifiers.

POWERMAG RESERCH series general functions

Stable pulse amplitude and width with full power output (100% intensity) up to 30 Hz for all stimulators.
There is no reduction in pulse output during stimulation.
Full external control is possible with analog, digital and trigger interfaces.
All single pulses can be set freely (shape, direction, intensity).
Continuous EEG recorded online with no power supply noise or recharging artifacts (not for PowerMAG LAB series)
A high speed synchronous output interface is available for phase synchronization with EEG amplifiers.

Man holding x-ray human brain in his han

Theta Burst Stimulation

シーターバースト刺激

PowerMAG series

LAB：PoweMAG

PowerMAG LAB 30
エントリーレベルの研究用磁気刺激装置は、最大30 Hzのr-TMSを利用でき、パルスとタイミングの精度、およびインターフェイスの可能性に関して妥協しません。
Power MAG LAB 30は、単一パルスおよびr-TMS刺激に最適なエントリーレベルの刺激装置です。パルスのタイミングと強度は常に正確で、再現性があります。
刺激装置はさまざまな方法で制御できるため、既存のセットアップに簡単に統合できます。
特徴
☑ 刺激中のパルス強度の低下なし
☑ 30 Hzまで100％の強度
☑ 完全な外部制御性
☑ 半波と全波が利用可能
☑ コイルの電流方向が反転可能

PowerMAG LAB 100

PowerMAG LAB 100は、TMS刺激装置のトップクラスに属しています。パルス間で再充電することにより、一定の強度で最大100Hzのパルスバーストを生成できます。 70％の強度で100Hzバーストの印象的な最大パルス周波数により、このデバイスはシータバーストプロトコルをiTBS、imTBSまたはcTBSとして使用するのに最適です。

特徴
☑ iTBS、imTBS、cTBSが可能
☑ 刺激中のパルス強度の低下なし
☑ 30 Hzまで100％の強度*
☑ 70％の強度で最大100 Hzのバースト*
☑ 完全な外部制御性
☑ 半波と全波が利用可能
☑ ボタンで反転可能なコイルの現在の方向

参考論文　Theta burst stimulation(シーターバースト刺激)

Ying-Zu Huang et al .2005 /Neuron, Vol. 45, 201–206, January 20, 2005 Theta Burst Stimulation Report of the Human Motor Cortex

Oberman et al.2012 Abnormal Modulation of Corticospinal Excitability in Adults with Asperger’s Syndrome, Eur J Neurosci. 2012 September ; 36(6): 2782–2788.

W.F. Stubbeman et al. / Brain Stimulation 11 (2018) 953e955 Bilateral neuronavigated 20Hz theta burst TMS for treatment refractory depression: An open label study

www.thelancet.com Vol 391 April 28, 2018 Effectiveness of theta burst versus high-frequency repetitive transcranial magnetic stimulation in patients with depression (THREE-D): a randomised non-inferiority trial

Hamada et al.2013 The Role of Interneuron Networks in Driving Human Motor Cortical Plasticity Cerebral Cortex July 2013;23:1593–1605

Jannati A, Block G, Ryan MA, Kaye HL, Kayarian FB, Bashir S, Oberman LM, Pascual-Leone A and Rotenberg A (2020) Continuous Theta-Burst Stimulation in Children With High-Functioning Autism Spectrum Disorder and Typically Developing Children. Front. Integr. Neurosci. 14:13

EEG：PowerMAG

Brain wave on electroencephalogram EEG f

オンラインTMS-EEG

TMS刺激時のノイズなし

TMSとEEGの自由な研究

PowerMAG series

POWERMAG EEG 100
Ultimate TMS research tool
PowerMAG EEG has been specially developed for high-end research users. Powerful high frequency TMS (including theta burst stimulus), precision single pulse and pair pulse protocols are available in one standalone device. In addition, it contains all the technical features of PowerMAG LAB Research.

オンラインTMS-EEG
皮質が磁気刺激されている間に脳波が調べる方法をオンラインTMS-EEGメソッドと呼ばれます。
これにより、短期および長期の両方の刺激効果を観察できます。
脳波の記録が刺激によって修復が出来ないほど乱されないことを保証するために、TMSシステムとEEGシステムの両方に特別な機器が必要です。オンラインのTMS-EEGメソッドは、その高い技術仕様により、PowerMAGリサーチシリーズの刺激装置で実行できます。

PowerMAG EEGの主な機能

☑ TMS刺激アーティファクト

5ms後のノイズのないEEGは、臨床情報の損失なしで記録を可能にします。

☑ コイル充電アーティファクト

コイルの再充電は、EEGデータに影響を与えません。

☑ 同期

高周波インターフェースを介したTMSとEEGの同期により、刺激アーチファクト補正、

EEG応答の評価、および平均応答の分析が可能になります。

☑ メインノイズ
特別なハードウェアコンセプトにより、EEG電極の電源ノイズの干渉がありません。
したがって、EEGノッチフィルターは廃止されます。

TMS-EEGシステムの次の概念を最適化

問題：刺激中の電極における電磁誘導

解決策：高度に開発されたコイルの技術により、非常に局所的な刺激パルスを発することができます。

さらに、パルス幅が短いため、パルス効率が高く高速神経刺激を引き起こすために必要なパルスエネルギーはごくわずかです。

問題：コイル再充電中の電極への電磁誘導

解決策：デバイスのコンセプトまたはロードディングのコンセプトを最適化したことで、EEG信号を乱すことなく、パルス後すぐにデバイスを再充電することが可能です。

これは、記録中にクリーンなEEG信号を受信するために極めて重要であるため、誤った判読を回避することができます（再充電のアーティファクトが生理学的応答に似ているため）。

問題：電極への電磁誘導された漏れ電流による電気的妨害

解決策：設計・製造における非常に高い基準により、漏れ電流を大幅に削減できます。品質シール「Made in Germany」および研究製品の開発と製造における長年の専門知識も重要な役割を果たします。

問題：コイルの動きによるSEP

解決策：MAG＆Moreコイルの設計とハウジングのコンセプトは、非常に人間工学に基づいた軽量のコイルの生産を可能にします。

これはアーチファクトの形成に強く影響します。

問題：「コイルのクリック」によるAEP

解決策：最新の製造プロセスにより、音響的に最適化された内部構造を持つ非常に静かなコイルを作成できます。

REAL TIME EEG TRIGEERED TMS

今日の脳刺激研究コミュニティのホットなトピックは、個人化されたTMSパターンを適用することによるリアルタイムの状態依存性による脳のネットワークの変調です。このリアルタイムアプリケーションを使用すると、ユーザーは、皮質の興奮性と、正しい「タイミング」と「正しい」TMS刺激に関して、ネットワーク経路における⾧期的な可塑性の誘導を調査できます。個々の刺激パターンのタイミングを実際の状態パラメーターと同期させることは技術的に困難です。さまざまな脳の状態のダイナミクスを追跡するには、EEGデータをリアルタイムで分析する必要があり、TMSデバイスを高精度でトリガーする必要があります。

S. Tremblay et al. / Clinical Neurophysiology Volume 130, Issue 5, May 2019, Pages 802-844 Clinical utility and prospective of TMS–EEG

Farzan et al. 2016 /Front Neural Circuits. 2016; 10: 73.Published online 2016 Sep 22. Characterizing and Modulating Brain Circuitry through Transcranial Magnetic Stimulation Combined with Electroencephalography

オールインワンソリューションTMSデバイスが登場

スタンドアロン型で2連発ペア刺激が可能です

シーターバースト刺激の出力も可能になりました

ppTMS PowerMAG

> PowerMAG LAB 30

Entry-level research magnetic stimulators can utilize r-TMS up to 30 Hz and do not compromise on pulse and timing accuracy and interface possibilities.

> PowerMAG LAB 100

A powerful stimulator capable of releasing r-TMS and theta burst stimuli up to 100 Hz burst.

> PowerMAG EEG 30

Adapted for use in online EEG studies, this stimulator can utilize r-TMS up to 30 Hz and does not compromise on pulse and timing accuracy and interface possibilities.

> PowerMAG EEG 100

The Power MAG EEG 100 is specially developed for high-end research users.

The powerful high frequency r-TMS (including theta burst stimulus) and high precision single pulse TMS are available in one standalone device, ready for use in online EEG studies.

> PowerMAG EEG ppTMS

The Power MAG ppTMS is a stand-alone r-TMS device that actively recharges between conditioning (S1) and test pulse (S2) to allow various ppTMS protocols, r-TMS protocols, within a single EEG machine. Theta burst protocol is available.

> PowerMAG QPS

The unique Power MAG QPS technology offers the opportunity to study very high frequency TMS in complex protocols.

Quattro pulses with only 1.5 ms between each pulse can be stimulated with stable and accurate parameters, and the magnetic stimulator is also compatible with online EEG.

Pair pulse TMS (ppTMS)

Using the ppTMS protocol, researchers can explore the inhibitory and excitatory effects of various motor and non-motor cortical regions.

ppTMS consists of two consecutive TMS stimuli. The first stimulus is called the conditioned stimulus (S1) and the second pulse is called the test stimulus (S2).

Proper Interstimulus Interval (ISI) in ppTMS uses PowerMAG technology to induce inhibitory or stimulatory effects on the motor cortex. Based on a biphasic pulse shape, it provides an all-in-one solution for r-TMS and ppTMS.

There are five observed effects depending on the ppTMS paradigm.

Intracortical facilitation (ICF)

To trigger the ICF, a backward-forward triggered sub-threshold S1 is followed by an on-threshold S2 with an ISI of 10-15 ms.

The observed effect is that the amplitude of the I wave is increased compared to when only S2 is delivered. Smoothing tends to be stronger with increasing S1 strength, but weaker with increasing S2 strength.

Long-interval Intracortical Facilitation (LICF)

If the threshold S1 is followed by a threshold S2 with an ISI of 10-30 ms, the second MEP is improved compared to the first MEP, indicating a stimulatory effect.

Long-latency Intracortical Inhibition (LICI)

If both S1 and 52 are above the threshold with an ISI of 50-200 ms, the second MEP will be reduced compared to the first. This is a sign of intracortical depression.

Short-interval Intracortical Facilitation (SICF)

SICF occurs when the upper threshold S1 is followed by the subthreshold S2 and the ISI is 1,1-1,5 ms.

The observed effect is a strengthening of the amplitude of the second l-wave.

SICF is suppressed when a subject first experiences sensory stimulation of associated peripheral nerves.

Short-interval Intracortical Inhibition (SICI)

If the ISI is 3 ms subthreshold S1 followed by subthreshold S2, the l wave is suppressed. SICI increases with S2 intensity.